5-HTP – Central Nervous System Support
5-HTP can be used as a precursor to serotonin, which can support endogenous serotonin and melatonin production. Serotonin is a very important calming neurotransmitter known as “the feel-good hormone.” In the Central Nervous System (CNS), serotonin has been implicated in the regulation of sleep, depression, anxiety, aggression, appetite, temperature, sexual behavior, and pain sensation.
When using 5-HTP for enhancing serotonin and melatonin production to promote calmness, healthy mood and sleep, reduction in pain perception and lessening of IBS symptoms, the addition of the synergistic nutrient pyridoxal-5-phospate, an activated form of vitamin B6, and vitamin B12 (as methylcobalamin) is suggested to catalyze the conversion of 5-HTP to serotonin (5-HT) and for proper methylation required for neurotransmitter production.
GABA Plus also includes the fully chelated magnesium malate involved in proper
nerve transmission, muscular contraction/relaxation and general relaxation responses.
Interactions with Drug Therapy
5-HTP may not be suitable to administer along with SSRI and MAOI medications
without clinical and laboratory monitoring. Please discuss this with your health care
provider before using this product with any of those medication classes.
Who should take GABA Plus?
GABA Plus should be considered for patients and consumers with:
• Increased levels of stress and anxiety
• Individuals who are easily agitated and frustrated
• Those with documented deficiencies in the neurotransmitters supported by GABA Plus
• Anyone with chronic global pain conditions
1. Plants and the central nervous system. Carlini EA. Pharmacol Biochem Behav 2003 Jun;75(3):501-12
2. L-Theanine reduces psychological and physiological stress responses. Kimura K, Ozeki M, Juneja L, Ohira H (2007)Biol Psychol 74 (1): 39–45.
3. Birdsall TC. 5-Hydroxytryptophan-A clinicall effective serotonin precursor..Altern Med Rev. 1998 Aug;3(4):271-80.
4. A review of phosphatidylserine pharmacological and clinical effects. Is phosphatidylserine a drug for the ageing brain? Pepeu, G., I.M. Pepeu, and L. Amaducci, Pharmacol Res, 1996.33(2): p. 73-80.
5. Textbook of Natural Medicine (2nd Ed.), Pizzorno JE, Murray MT. Churchill Livingstone, New York, 1999.
6. Complimentary & Alternative Medicines: Professional’s Handbook. Fetrow CW, Avila JR. Springhouse, Springhouse, PA, 1999.
7. Botanical Influences on Illness: A sourcebook of clinical research. Werbach MR, Murray, MT. Third Line Press, Tarzana, California, 1994.
8. Incorporating Herbal Medicine Into Clinical Practice. Bascom A. F.A. Davis Co., Philadelphia, 2002.
9. Encyclopedia of Herbal Medicine. Cheallier A. Dorling Kindersley, London, 2000.
10. Pharmacognosy and Pharmacobiotechnology. Robbers JE, Speedie MK, Tyler VE. Williams & Wilkins, Baltimore, 1996.
11. PDR for Nutritional Supplements, 1st Ed. Medical Economics/Thompson Healthcare, 2001.
12. PDR for Herbal Medicines, 1st Ed. Medical Economics/Thompson Healthcare, 1998.